Welcome to the home of Qwitter
What is it?
Qwitter is an accessible Twitter client designed for access by the blind, providing an innovative integration between Twitter and a user's screen reader.
The Qwitter client enables blind individuals to interface with the Twitter service globally, regardless of application focus. Based off of revolutionary concepts pioneered in The Jawter Jaws Scripts, Qwitter, with full support for the three major comercial screen readers and sapi speech, provides you instant access to all aspects of the twitter microblogging service, giving you the ability to post a tweet from anywhere, read tweets, perform searches, and far, far more.
How does it work?
For a very comprehensive look at Qwitter, and all of its features, capabilities, and quirks, try
The fantastic readme document
Alternatively, you can visit the wiki for lots of useful information which has been contributed by users of the program.